Involvement of Aquaporin 4 in Astrocyte Function and Neuropsychiatric Disorders

Aquaporin-4 knockout exacerbates corticosterone-induced depression by inhibiting astrocyte function and hippocampal neurogenesis.

AIMS The predominant expression of aquaporin-4 (AQP4) in the brain implies that this water channel may be involved in a range of brain disorders. This study was designed to investigate the role of AQP4 in the pathogenesis of depression, and related possible biological mechanism. METHODS AND RESULTS Wild-type (AQP4(+/+) ) and AQP4 knockout (AQP4(-/-) ) mice were given daily subcutaneous inject...

Gut Microbiota and Neuropsychiatric Disorders

‏‎interpersonal function of language in subtitling

‏‎translation as a comunicative process is always said to be associated with various aspects of meaning loss or gain. subtitling as a mode of translating, due to special discoursal and textual conditions imposed upon it, is believed to be an obvious case of this loss or gain. presenting the spoken sound track of a film in writing and synchronizing the perception of this text by the viewers with...

Oestrogen, brain function, and neuropsychiatric disorders.

research on the neurobiological effects of oestrogen. Also, health professionals are being asked for guidance on whether women should be prescribed oestrogen and progestogen hormone replacement therapy (HRT) not only to treat vasomotor instability and reduce bone loss, but also in various neuropsy-chiatric disorders. However, it is controversial whether oestrogen is indicated in the treatment o...

Astrocyte Aquaporin Dynamics in Health and Disease

The family of aquaporins (AQPs), membrane water channels, consists of diverse types of proteins that are mainly permeable to water; some are also permeable to small solutes, such as glycerol and urea. They have been identified in a wide range of organisms, from microbes to vertebrates and plants, and are expressed in various tissues. Here, we focus on AQP types and their isoforms in astrocytes,...